Anti-Plexin-B2 antibodies, human

Anti-Plexin-B2 antibodies, human

Clone: REA626 | Dilution: 1:11
Clone REA626 recognizes the human plexin-B2 antigen, a single-pass type I membrane protein, which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T cell–dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells, and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth, and cell migration. It has several semaphorin ligands including semaphorin-3E, semaphorin-4A, semaphorin-4C, and semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with plexin-B2 on γδ T cells to play a role in the healing process.
Additional information: Clone REA626 displays negligible binding to Fc receptors.

Alternative Names

Plxnb2, MM1, Nbla00445, dJ402G11.3

Technical specifications

  • Antigen: Plexin-B2
  • Clone: REA626
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Plxnb2, MM1, Nbla00445, dJ402G11.3
  • Entrez Gene ID: 23654
  • Molecular mass of antigen [kDa]: 203
  • Distribution of antigen: dendritic cells, macrophages, T cells, astrocytes, microglia, neurons, oligodendrocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected References

    1. Deng, S. et al. (2007)
      Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system
      in vivo
      .
      J. Neurosci. 27(23): 6333-6347
    2. Witherden, D.A. et al. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity 37(2): 314-325
    3. Le, A. P. et al. (2015) Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget 6(9): 7293-7304
Product options: 6

Product information

Size
Order no.
Price

Anti-Plexin-B2-PE, human

  • REA626
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-771
-

Anti-Plexin-B2-PE, human

  • REA626
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-724
-

Anti-Plexin-B2-APC, human

  • REA626
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-772
-

Anti-Plexin-B2-APC, human

  • REA626
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-725
-

Anti-Plexin-B2-PE-Vio770, human

  • REA626
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-773
-

Anti-Plexin-B2-PE-Vio770, human

  • REA626
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-726
-