Anti-PLC-γ2 pY759 antibodies, human

Anti-PLC-γ2 pY759 antibodies, human

Clone: REA341
Clone REA341 recognizes the phosphoinositide phospholipase C-gamma-2 (PLC-γ2) antigen phosphorylated at tyrosine 759 (pY759). PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell antigen receptors) that are linked to the activation of nonreceptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Phosphorylation of PLC-γ2 at tyrosines 753 and 759 leads to activation of the enzyme. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells.
Additional information: Clone REA341 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: PLC-γ2 pY759
  • Clone: REA341
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
  • Entrez Gene ID: 5336
  • Molecular mass of antigen [kDa]: 148
  • Distribution of antigen: ubiquitous, hematopoietic stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
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