Anti-PLC-γ2 antibodies, human

Anti-PLC-γ2 antibodies, human

Clone: REA488 | Dilution: 1:11
Clone REA488 recognizes the human phosphoinositide phospholipase C-γ-2 (PLC-γ2) antigen regardless of phosphorylation status. PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell–antigen receptors) that are linked to the activation of non-receptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells.
Additional information: Clone REA488 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: PLC-γ2
  • Clone: REA488
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
  • Entrez Gene ID: 5336
  • Molecular mass of antigen [kDa]: 148
  • Cross-reactivity: mouse
  • Distribution of antigen: B cells, hematopoietic stem cells, leukocytes, monocytes, macrophages, NK cells, platelets, lymphocytes, T cells, T helper cells, thymocytes, NKT cells, basophils, eosinophils, mast cells, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
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