Anti-PKCα pT497 antibodies, human

Anti-PKCα pT497 antibodies, human

Clone: REA821 | Dilution: 1:50
Clone REA821 recognizes the PKCα antigen phosphorylated at threonine 497. PKCα has been reported to crossreact with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca
handling in myocytes.
Additional information: Clone REA821 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: PKCα pT497
  • Clone: REA821
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
  • Entrez Gene ID: 5578
  • Molecular mass of antigen [kDa]: 77
  • Distribution of antigen: cancer cells, breast cancer cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
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