Anti-PKCα antibodies, human

Anti-PKCα antibodies, human

Clone: REA156 | Dilution: 1:11
Clone REA156 recognizes the PKCα antigen regardless of its phosphorylation status. It has been reported to cross-react with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays a role in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca
2+
handling in myocytes.
Additional information: Clone REA156 displays negligible binding to Fc receptors.

Alternative names

PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Technical specifications

  • Antigen: PKCα
  • Clone: REA156
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
  • Entrez Gene ID: 5578
  • Molecular mass of antigen [kDa]: 77
  • Cross-reactivity: mouse, rat, dog, chicken, frog
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PerCP-Vio700
  • Selected references

    1. Finkenzeller, G. et al. (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res. 18(8): 2183
    2. Koivunen, J. et al. (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett. 235(1): 1-10
    3. Xu, H. et al. (2008) Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78(2): 349-355
Product options: 6
130-103-688

Anti-PKCα-PE, human

for 30
tests
(1)
-
130-103-623

Anti-PKCα-PE, human

for 100
tests
(1)
-
130-103-689

Anti-PKCα-APC, human

for 30
tests
(1)
-
130-103-624

Anti-PKCα-APC, human

for 100
tests
(1)
-
130-103-690

Anti-PKCα-PerCP-Vio700, human

for 30
tests
(1)
-
130-103-625

Anti-PKCα-PerCP-Vio700, human

for 100
tests
(1)
-