Anti-PCNA antibodies, human, mouse, rat

Anti-PCNA antibodies, human, mouse, rat

Clone:
REA858
| Dilution: 1:50
Clone REA858 recognizes the human, mouse, and rat proliferating cell nuclear antigen (PCNA), a 36 kDa nuclear protein also known as cyclin or auxiliary protein of DNA polymerase delta. PCNA is expressed in the nucleus of all proliferating cells. PCNA plays a role in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Furthermore, it is involved in DNA damage response by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.
Additional information: Clone REA858 displays negligible binding to Fc receptors.

Alternative Names

proliferating-cell-nuclear-antigen, Cyclin

Technical specifications

  • Antigen: PCNA
  • Clone:
    REA858
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: proliferating-cell-nuclear-antigen, Cyclin
  • Entrez Gene ID: 5111, 18538, 25737
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    , chicken, rabbit, hamster, horse, sheep, dog, cat, ferret, xenopus
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515
  • Selected References

    1. Landberg, G. et al. (1990) Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp. Cell Res. 187(1): 111-118
    2. Guzińska-Ustymowicz, K. et al. (2009) Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Res. 29(8): 3049-3052
    3. Cazzalini, O. et al. (2014) CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 42(13): 8433-8448
    4. Ortega, J. et al. (2015) Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 112(18): 5667-5672
Product options: 8

Product information

Size
Order no.
Price

Anti-PCNA-FITC, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 30
tests
(1)
130-114-702
-

Anti-PCNA-FITC, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 100
tests
(1)
130-114-511
-

Anti-PCNA-PE, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 30
tests
(1)
130-114-703
-

Anti-PCNA-PE, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 100
tests
(1)
130-114-512
-

Anti-PCNA-APC, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 30
tests
(1)
130-114-704
-

Anti-PCNA-APC, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 100
tests
(1)
130-114-513
-

Anti-PCNA-Vio515, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 30
tests
(1)
130-114-705
-

Anti-PCNA-Vio515, human, mouse, rat

  • REA858
  • 1:50
  • For research use only
for 100
tests
(1)
130-114-514
-