Anti-p70 S6 Kinase antibodies, human, mouse, rat

Anti-p70 S6 Kinase antibodies, human, mouse, rat

Clone: REA843 | Dilution: 1:50
Clone REA843 recognizes the intracellular p70 S6 Kinase, also known as ribosomal protein S6 kinase beta-1. It is a serine/threonine kinase that is widely expressed in the cytosol and in the nucleus. It mediates cell cycle progression and is involved in the regulation of protein synthesis. The p70 S6 kinase is localized in cytosol and in the nucleus, after cytokine stimulation. TNF-receptor activation leads to activation of the p70 S6 kinase, which increases protein synthesis and cell proliferation. In addition, p70 S6 kinase is a major effector of mammalian target of rapamycin (mTOR) phosphorylation.
Additional information: Clone REA843 displays negligible binding to Fc receptors.

Alternative Names

S6K-beta-1, S6K1, P70S6K1, p70-S6K 1

Technical specifications

  • Antigen: p70 S6 Kinase
  • Clone: REA843
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: S6K-beta-1, S6K1, P70S6K1, p70-S6K 1
  • Entrez Gene ID: 6198, 72508, 83840
  • Molecular mass of antigen [kDa]: 59
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515
  • Selected references

    1. Gout, I. et al. (1998) Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. J. Biol. Chem. 273(46): 30061-30064
    2. Fleckenstein, D. S. et al. (2003) Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. Leuk. Res. 27(8): 687-694
    3. Holz, M. K. et al. (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280(28): 26089-26093
Product options: 8
130-112-923

Anti-p70 S6 Kinase-FITC, human, mouse, rat

for 30
tests
(1)
-
130-112-734

Anti-p70 S6 Kinase-FITC, human, mouse, rat

for 100
tests
(1)
-
130-112-924

Anti-p70 S6 Kinase-PE, human, mouse, rat

for 30
tests
(1)
-
130-112-735

Anti-p70 S6 Kinase-PE, human, mouse, rat

for 100
tests
(1)
-
130-112-925

Anti-p70 S6 Kinase-APC, human, mouse, rat

for 30
tests
(1)
-
130-112-736

Anti-p70 S6 Kinase-APC, human, mouse, rat

for 100
tests
(1)
-
130-112-926

Anti-p70 S6 Kinase-Vio515, human, mouse, rat

for 30
tests
(1)
-
130-112-737

Anti-p70 S6 Kinase-Vio515, human, mouse, rat

for 100
tests
(1)
-