Anti-p53 acK382 antibodies, human

Anti-p53 acK382 antibodies, human

Clone: REA529 | Dilution: 1:11
Clone REA529 recognizes the human cellular tumor antigen p53 acetylated in the C-terminal region at lysine 382 (acK382). The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. The acetylation levels of p53 are significantly enhanced in response to stress and correlate well with p53 activation and stabilization. p53 acetylation at K382 plays an important role in depsipeptide-induced p21(Waf1/Cip1) expression.
Additional information: Clone REA529 displays negligible binding to Fc receptors.

Alternative Names

TP53, BCC7, LFS1, TRP53, NY-CO-13

Technical specifications

  • Antigen: p53 acK382
  • Clone: REA529
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: TP53, BCC7, LFS1, TRP53, NY-CO-13
  • Entrez Gene ID: 7157
  • Molecular mass of antigen [kDa]: 44
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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