Anti-p120 Catenin pT916 antibodies, human and mouse

Anti-p120 Catenin pT916 antibodies, human and mouse

Clone: REA129 | Dilution: 1:11
Clone REA129 recognizes the T916-phosphorylated form of p120 Catenin, a prototypic member of subfamily of armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Furthermore, lack of p120 Catenin in mouse leads to tumor development, suggesting its further role as tumor supressor. Phosphorylation of p120 Catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases.
Additional information: Clone REA129 displays negligible binding to Fc receptors.

Alternative Names

CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Technical specifications

  • Antigen: p120 Catenin pT916
  • Clone: REA129
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CTNND1, CAS, CTNND, p120cas, p120ctn, p120
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
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