Anti-Notch3 antibodies, human

Anti-Notch3 antibodies, human

Clone: MHN3-21 | Dilution: 1:11
The MHN3-21 monoclonal antibody reacts with the extracellular domain of human Notch3, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multi-protein complex. Notch3 is expressed on various various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. It can also be expressed on vascular smooth muscle and cells of the central nervous system. In addition, the altered expression of Notch3 by various leukemias, lymphomas, and cancers has been reported.

Alternative Names


Technical specifications

  • Antigen: Notch3
  • Clone: MHN3-21
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CADASIL, CASIL, IMF2, LMNS
  • Entrez Gene ID: 4854
  • Molecular mass of antigen [kDa]: 240
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin

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