Anti-Notch2 antibodies, human

Anti-Notch2 antibodies, human

Dilution: 1:11
The MHN2-25 mononuclear antibody reats with the extracellular domain of human Notch2, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multiprotein complex. Notch2 is expressed on various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. In addition, the altered expression of Notch2 in various leukemias, lymphomas, and cancers has been reported.

Alternative Names

AGS2, HJCYS, hN2

Technical specifications

  • Antigen: Notch2
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: AGS2, HJCYS, hN2
  • Entrez Gene ID: 4853
  • Molecular mass of antigen [kDa]: 263
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
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