Anti-NLRP3 (NALP3) antibodies, human and mouse

Anti-NLRP3 (NALP3) antibodies, human and mouse

Clone: REA668 | Dilution: 1:50
Clone REA668 recognizes the human and mouse NLRP3 antigen, also known as NACHT, LRR, and PYD domains–containing protein 3 (NALP3). NLRP3, a member of the NLR family of cytosolic receptors, is a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. NLRP3 plays a crucial role in innate immunity and inflammation and is a pathogen recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. NLRP3 is mainly expressed in macrophages, but also expressed in dendritic cells, B cells, T cells, and osteoblasts.
Additional information: Clone REA668 displays negligible binding to Fc receptors.

Alternative Names

NACHT, LRR, PYD domains-containing protein 3, NALP3, cryopyrin

Technical specifications

  • Antigen: NLRP3 (NALP3)
  • Clone: REA668
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: NACHT, LRR, PYD domains-containing protein 3, NALP3, cryopyrin
  • Entrez Gene ID: 114548, 216799
  • Molecular mass of antigen [kDa]: 118
  • Distribution of antigen: B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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