Anti-Microfold (M) Cells antibodies – functional grade, mouse

Anti-Microfold (M) Cells antibodies – functional grade, mouse

Clone: NKM 16-2-4 
Clone NKM 16-2-4 specifically binds (1,2)-fucose–containing carbohydrate moieties on murine microfold cells (M cells or membranous cells). Villous M cells are located in follicle-associated epithelium of Peyer’ s patches (PPs) and nasopharynx-associated lymphoid tissue (NALT). NKM 16-2-4 specifically binds to all subsets of M cells, but not epithelial cells or goblet cells located in PPs, NALT, and the intestinal villi in the gastrointestinal or respiratory tracts.
Microfold cells or membranous cells (M cells) have a high transcytotic activity and play an important role in the uptake of luminal antigens for induction of antigen-specific immune responses. This antibody (clone NKM 16-2-4) specifically binds to all subsets of M cells, but not epithelial cells or goblet cells located in Peyer's patches, nasopharynx-associated lymphoid tissue, and the intestinal villi in the gastrointestinal or respiratory tracts.

Applications

The Anti-Microfold (M) Cells pure – functional grade antibody is suited for functional assays, for example, antibody-mediated vaccination studies.

Technical specifications

  • Antigen: Microfold
  • Clone: NKM 16-2-4 
  • Isotype: rat IgG2c
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
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