Anti-MICA/MICB antibodies, human

Anti-MICA/MICB antibodies, human

Clone: 6D4 | Dilution: 1:11
The monoclonal antibody 6D4 recognizes MICA and MICB, which are transmembrane glycoproteins related to major histocompatibility complex (MHC) class I molecules. In contrast to other MHC class I proteins, MICA/B have no association with β2-microglobulin and do not bind peptides. They are ligands for NKG2D, which is expressed on NK cells and many T cells. MICA/B are expressed on endothelial cells and fibroblasts and are stress-induced in epithelial cells.

Alternative names

MICB, PERB11.2, MICA, PERB11.1

Technical specifications

  • Antigen: MICA/MICB
  • Clone: 6D4
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: MICB, PERB11.2, MICA, PERB11.1
  • Distribution of antigen: endothelial cells, fibroblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Li, P. et al. (1999) Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand. Immunity 10: 577-584
    2. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
    3. Bauer, S. et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729
Product options: 12
130-106-151

Anti-MICA/MICB-VioBright FITC, human

for 30
tests
(1)
-
130-106-100

Anti-MICA/MICB-VioBright FITC, human

for 100
tests
(1)
-
130-100-889

Anti-MICA/MICB-PE, human

for 30
tests
(1)
-
130-100-886

Anti-MICA/MICB-PE, human

for 100
tests
(1)
-
130-100-882

Anti-MICA/MICB-APC, human

for 30
tests
(1)
-
130-100-881

Anti-MICA/MICB-APC, human

for 100
tests
(1)
-
130-100-927

Anti-MICA/MICB-PE-Vio770, human

for 30
tests
(1)
-
130-100-925

Anti-MICA/MICB-PE-Vio770, human

for 100
tests
(1)
-
130-101-053

Anti-MICA/MICB-APC-Vio770, human

for 30
tests
(1)
-
130-100-884

Anti-MICA/MICB-APC-Vio770, human

for 100
tests
(1)
-
130-100-904

Anti-MICA/MICB-Biotin, human

for 30
tests
(1)
-
130-100-901

Anti-MICA/MICB-Biotin, human

for 100
tests
(1)
-

Related products

3 products available