Anti-Ly-49A antibodies, mouse

Anti-Ly-49A antibodies, mouse

Clone: REA1018 | Dilution: 1:50
Clone REA1018 recognizes th mouse Ly-49A antigen, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk, and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells.
Additional information: Clone REA1018 displays negligible binding to Fc receptors.

Alternative Names

Klra1, CH29-493D4.3, Klra22, Ly49v

Technical specifications

  • Antigen: Ly-49A
  • Clone: REA1018
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Klra1, CH29-493D4.3, Klra22, Ly49v
  • Entrez Gene ID: 16627
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
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