Anti-LAT pY226 antibodies, human

Anti-LAT pY226 antibodies, human

Clone: REA146 | Dilution: 1:11
Clone REA146 recognizes LAT phosphorylated at tyrosine 226. Linker of T cell activation (LAT), a transmembrane adaptor molecule, is constitutively localized in the lipid rafts and is involved in transducing the signal initiated by triggered T cell receptor (TCR). Upon TCR engagement, SRC and SYK family of protein tyrosine kinases (PTKs) are activated and LAT is phosphorylated at multiple conserved tyrosine residues in its cytosolic domain by Syk-family PTK Zap-70. Phosphorylated LAT can associate with several downstream SH2 domain containing proteins such as GRB2, PLCy1, ITK, GADS, and p85 subunit of PI3K to propagate the TCR activation signal and to activate several downstream pathways. pY226 motif can be bound directly by GRB2, GADS, and PLC-y1. Expression of LAT is found in thymocytes, T cells, mast cells, natural killer (NK cells), and platelets. Thymocytes lacking LAT are completely blocked at the pro-T3 stage in thymopoiesis.
Additional information: Clone REA146 displays negligible binding to Fc receptors.

Alternative Names

LAT1, pp36

Technical specifications

  • Antigen: LAT pY226
  • Clone: REA146
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: LAT1, pp36
  • Entrez Gene ID: 27040
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: NK cells, mast cells, platelets, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
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