Anti-KLRG1 antibodies, human

Anti-KLRG1 antibodies, human

Clone: REA261 | Dilution: 1:11
Clone REA261 recognizes the killer cell lectin-like receptor subfamily G member 1 (KLRG1) antigen, a transmembrane protein, which is also known as C-type lectin domain family 15 member A (CLEC15A) or ITIM-containing receptor MAFA-L. KLRG1 is expressed by basophils, CD4 and CD8 T cells that exhibit a memory cell phenotype, and by a large proportion of peripheral blood NK cells. Expression of KLRG1 by virus-specific CD8
T cells is induced by repetitive antigen stimulation and it differs in chronic versus resolved viral infections. T cells expressing KLRG1 exhibit a poor proliferation potential, while their ability to secrete gamma interferon is preserved. Thus, KLRG1 is a convenient marker for early T cell–differentiation.
Additional information: Clone REA261 displays negligible binding to Fc receptors.

Alternative Names

Killer cell lectin-like receptor subfamily G member 1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, 2F1
REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the different hybridoma clones. 
Other clonesOverlap in epitope recognition with REA261

Technical specifications

  • Antigen: KLRG1
  • Clone: REA261
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Killer cell lectin-like receptor subfamily G member 1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, 2F1
  • Entrez Gene ID: 10219
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: basophils, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, PE-Vio615, PE-Vio770, APC-Vio770, Biotin
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