Anti-KIR2D antibodies, human

Anti-KIR2D antibodies, human

Clone: NKVFS1 | Dilution: 1:11
The Anti-KIR2D antibody recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56
dim
CD16
+
natural killer (NK) cells and a subset of CD8
+
T cells. KIRs contribute to the regulation of NK cell-mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS).

Alternative names

CD158A

Technical specifications

  • Antigen: KIR2D
  • Clone: NKVFS1
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CD158A
  • Entrez Gene ID: 3806, 100132285, 3808, 3809, 3810, 3802, 3803, 3804, 3805, 57292
  • Molecular mass of antigen [kDa]: 31-39
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, Biotin, pure
  • Selected references

    1. Djeu, J. et al. (2002) A view to a kill: signals triggering cytotoxicity. Clin. Cancer Res. 8: 636-640
    2. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
    3. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
Product options: 13
130-098-681

Anti-KIR2D-FITC, human

for 30
tests
(1)
-
130-098-689

Anti-KIR2D-FITC, human

for 100
tests
(1)
-
130-099-417

Anti-KIR2D-PE, human

for 30
tests
(1)
-
130-092-688

Anti-KIR2D-PE, human

for 100
tests
(1)
-
130-099-649

Anti-KIR2D-APC, human

for 30
tests
(1)
-
130-092-687

Anti-KIR2D-APC, human

for 100
tests
(1)
-
130-099-042

Anti-KIR2D-VioBlue, human

for 30
tests
(1)
-
130-099-040

Anti-KIR2D-VioBlue, human

for 100
tests
(1)
-
130-108-375

Anti-KIR2D-VioGreen, human

for 30
tests
-
130-108-344

Anti-KIR2D-VioGreen, human

for 100
tests
-
130-100-175

Anti-KIR2D-Biotin, human

for 30
tests
(1)
-
130-092-904

Anti-KIR2D-Biotin, human

for 100
tests
(1)
-
130-092-689

Anti-KIR2D pure, human

100 µg in 1 mL
-