Anti-IRF-8 antibodies, human and mouse

Anti-IRF-8 antibodies, human and mouse

Clone: REA516 | Dilution: 1:11
Clone REA516 recognizes the human and mouse interferon regulatory factor 8 (IRF-8) antigen, a 50 kDa transcription factor, which is also known as interferon consensus sequence–binding protein (ICSBP). IRF-8 belongs to the family of interferon regulatory transcription factors, which consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain with a unique tryptophan pentad repeat. IRF-8 is expressed at very high levels in mononuclear phagocytes, and regulates granulocyte/macrophage differentiation and dendritic cell (DC) development. Acting in heterodimeric complexes with other transcription factors, IRF-8 also controls the transcriptional response of mature myeloid cells to interferons and Toll-like receptor agonists, a response in which IRF-8 binds and transactivates the promotors of IL12B and NOS2. IRF-8 knockout mice display a loss of CD8a
lymphoid DCs, CD103
tissue myeloid DCs, and plasmacytoid DCs.
Additional information: Clone REA516 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: IRF-8
  • Clone: REA516
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B
  • Entrez Gene ID: 3394, 15900
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: dendritic cells, granulocytes, monocytes, macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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