Anti-IRF-7 pS477/pS479 antibodies, human

Anti-IRF-7 pS477/pS479 antibodies, human

Clone: REA310 | Dilution: 1:11
Clone REA310 recognizes the interferon regulatory factor 7 (IRF-7) phosphorylated at serines 477 and 479 (pS477/pS479). IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes.
Additional information: Clone REA310 displays negligible binding to Fc receptors.

Alternative Names

IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C

Technical specifications

  • Antigen: IRF-7 pS477/pS479
  • Clone: REA310
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C
  • Entrez Gene ID: 3665
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: lymphocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
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