Anti-IRF-7 antibodies, human

Anti-IRF-7 antibodies, human

Clone: REA521 | Dilution: 1:11
Clone REA521 recognizes the human interferon regulatory factor 7 (IRF-7) antigen, regardless of phosphorylation status. IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes.
Additional information: Clone REA521 displays negligible binding to Fc receptors.

Alternative names

IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C

Technical specifications

  • Antigen: IRF-7
  • Clone: REA521
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C
  • Entrez Gene ID: 3665
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: dendritic cells, lymphocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Zhang L. et al. (1997) IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol. Cell. Biol. 17(10): 5748-5757
    2. Smith, E. J. et al. (2001) IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J. Biol. Chem. 276(12): 8951-8957
    3. Sgarbanti, M. et al. (2007) IRF-7: new role in the regulation of genes involved in adaptive immunity. Ann. N. Y. Acad. Sci. 1095: 325-333
Product options: 6
130-108-904

Anti-IRF-7-FITC, human

for 30
tests
(1)
-
130-108-874

Anti-IRF-7-FITC, human

for 100
tests
(1)
-
130-108-905

Anti-IRF-7-PE, human

for 30
tests
(1)
-
130-108-875

Anti-IRF-7-PE, human

for 100
tests
(1)
-
130-108-906

Anti-IRF-7-APC, human

for 30
tests
(1)
-
130-108-876

Anti-IRF-7-APC, human

for 100
tests
(1)
-