Anti-Integrin β6 antibodies, human

Anti-Integrin β6 antibodies, human

Clone: REA748 | Dilution: 1:50
Clone REA748 recognizes the human integrin β6 antigen, a 95 kDa type I transmembrane glycoprotein which is a member of the integrin β family. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. Integrin β6, also known as ITGB6, is a receptor for fibronectin and cytotactin and interacts with coxsackievirus A9 and coxsackievirus B1 proteins. Integrin β6 forms heterodimers with integrin αV. Internalisation of integrin αV/β6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Additional information: Clone REA748 displays negligible binding to Fc receptors.

Alternative names

ITGB6, Integrin beta-6

Technical specifications

  • Antigen: Integrin β6
  • Clone: REA748
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGB6, Integrin beta-6
  • Entrez Gene ID: 3694
  • Molecular mass of antigen [kDa]: 84
  • Distribution of antigen: epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Agrez, M. V. et al. (1997) Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Virology 239(1): 71-77
    2. Ramsay, A. G. et al. (2007) HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res. 67(11): 5275-5284
    3. Gianni, T. et al. (2013) αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. PLoS Pathog. 9(12)
Product options: 8
130-111-455

Anti-Integrin β6-VioBright FITC, human

for 30
tests
(1)
-
130-111-269

Anti-Integrin β6-VioBright FITC, human

for 100
tests
(1)
-
130-111-453

Anti-Integrin β6-PE, human

for 30
tests
(1)
-
130-111-267

Anti-Integrin β6-PE, human

for 100
tests
(1)
-
130-111-454

Anti-Integrin β6-APC, human

for 30
tests
(1)
-
130-111-268

Anti-Integrin β6-APC, human

for 100
tests
(1)
-
130-111-452

Anti-Integrin β6-Biotin, human

for 30
tests
(1)
-
130-111-266

Anti-Integrin β6-Biotin, human

for 100
tests
(1)
-