Anti-IL-21 antibodies, human

Anti-IL-21 antibodies, human

Clone: REA1039 | Dilution: 1:50
Clone REA1039 recognizes the human interleukin 21 (IL-21), which is secreted by a certain subset of CD4
+
T cells, called T follicular helper (Tfh) cells, also characterized by the expression of CXCR5 and ICOS and the lineage-specific transcription factor BCL6. But IL-21 production can also be found in other T helper cell lineages and natural killer T (NKT) cells. IL-21 acts in a autocrine manner on Tfh cells and is critical for antibody production by B cells, it enhances natural killer (NK) cell functions, and promotes proliferation of CD8
+
T cell.
Additional information: Clone REA1039 displays negligible binding to Fc receptors.

Alternative Names

CVID11, Za11

Technical specifications

  • Antigen: IL-21
  • Clone: REA1039
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CVID11, Za11
  • Entrez Gene ID: 59067
  • Molecular mass of antigen [kDa]: 15
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio667

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