Anti-IL-2 antibodies, human

Anti-IL-2 antibodies, human

Clone: REA689 | Dilution: 1:50
Clone REA689 recognizes the human interleukin-2 (IL-2), a cytokine which is produced by cells that are involved in inflammatory immune responses. IL-2 is rapidly secreted by naive CD4
+
T cells and by central memory T cells upon activation. It promotes growth and differentiation of T cells and has pleiotropic effects on many other leukocytes.
Additional information: Clone REA689 displays negligible binding to Fc receptors.

Alternative names

T cell growth factor, TCGF

Technical specifications

  • Antigen: IL-2
  • Clone: REA689
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: T cell growth factor, TCGF
  • Entrez Gene ID: 3558
  • Molecular mass of antigen [kDa]: 15
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770

Specificity

In order to compare the epitope specificity of REAfinity Clone REA689 with other known clones, a competition assay was performed. 
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA689
N7.48A-
REA105+
MQ1-17H12++
  • Selected references

    1. Fujita, T. et al. (1983) Structure of the human interleukin 2 gene. Proc. Natl. Acad. Sci. U.S.A. 80(24): 7437-7441
    2. Gaffen, S. L. et al. (2004) Overview of interleukin-2 function, production and clinical applications. Cytokine 28(3): 109-123
    3. Liao, W. et al. (2011) IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr. Opin. Immunol. 23(5): 598-604
Product options: 12
130-111-488

Anti-IL-2-FITC, human

for 30
tests
(1)
-
130-111-302

Anti-IL-2-FITC, human

for 100
tests
(1)
-
130-111-489

Anti-IL-2-PE, human

for 30
tests
(1)
-
130-111-303

Anti-IL-2-PE, human

for 100
tests
(1)
-
130-111-490

Anti-IL-2-APC, human

for 30
tests
(1)
-
130-111-304

Anti-IL-2-APC, human

for 100
tests
(1)
-
130-111-493

Anti-IL-2-PE-Vio615, human

for 30
tests
(1)
-
130-111-307

Anti-IL-2-PE-Vio615, human

for 100
tests
(1)
-
130-111-491

Anti-IL-2-PE-Vio770, human

for 30
tests
(1)
-
130-111-305

Anti-IL-2-PE-Vio770, human

for 100
tests
(1)
-
130-111-492

Anti-IL-2-APC-Vio770, human

for 30
tests
(1)
-
130-111-306

Anti-IL-2-APC-Vio770, human

for 100
tests
(1)
-