Anti-IL-17A antibodies – functional grade, mouse

Anti-IL-17A antibodies – functional grade, mouse

Clone: TC11-18H10
Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders. Data from several mouse models suggest that IL-17 plays a key role in host defense against certain extracellular bacterial infections. IL-17–producing CD4
+
T helper (Tʜ17) cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. After stimulation of mouse T cells, IL-17 is not only secreted by CD4
+
T cells, but also by CD8
+
T cells, γδ T cells, NK cells, and granulocytes.

Applications

This pure – functional grade antibody is suited for functional assays, for example, neutralization of cytokine activity.

Alternative Names

CTLA-8, IL-17

Technical specifications

  • Antigen: IL-17A
  • Clone: TC11-18H10
  • Isotype: rat IgG1
  • Alternative names of antigen: CTLA-8, IL-17
  • Entrez Gene ID: 16171
  • Molecular mass of antigen [kDa]: 15
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected References

    1. Ouyang, W. et al. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467
    2. Weaver, C. T. et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852
Product options: 1

Product information

Size
Order no.
Price

Anti-IL-17A pure - functional grade, mouse

  • TC11-18H10
  • For research use only
500 µg in 0.5 mL
130-095-732
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