Anti-IL-12R β2 antibodies, human

Anti-IL-12R β2 antibodies, human

Clone: REA333 | Dilution: 1:11
Clone REA333 recognizes the human interleukin-12 receptor subunit beta-2 (IL-12R β2) antigen, a single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon γ. IL-12R β2 is expressed by Tʜ1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Tʜ1 differentiation. The IL-12R β2 subunit plays an important role in Tʜ1 cell differentiation, since its absence leads to an abortive Tʜ1 differentiation that has dysfunctional production of Tʜ1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Additional information: Clone REA333 displays negligible binding to Fc receptors.

Alternative Names

IL12RB2

Technical specifications

  • Antigen: IL-12R β2
  • Clone: REA333
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL12RB2
  • Entrez Gene ID: 3595
  • Molecular mass of antigen [kDa]: 95
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
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