Anti-IFN-γ antibodies, mouse

Anti-IFN-γ antibodies, mouse

Clone: REA638 | Dilution: 1:50
Clone REA638 recognizes the mouse interferon-γ (IFN-γ) antigen, a secreted protein which is produced by activated T, B, and NK cells. IFN-γ is a pleiotropic cytokine responsible for macrophage activation and differentiation. It induces transcription of several proinflammatory genes, such as inducible NO synthase, cyclooxygenase-2, and IL-1β, as well as MHC proteins. IFN-γ, in synergy with other cytokines such as TNF-α, inhibits proliferation of normal and transformed cells. Immunomodulatory effects of IFN-γ are exerted on a wide range of cell types expressing the high affinity receptors for IFN-γ.
Additional information: Clone REA638 displays negligible binding to Fc receptors.

Alternative names

Gamma-interferon, IFN-gamma, IFNg

Technical specifications

  • Antigen: IFN-γ
  • Clone: REA638
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Gamma-interferon, IFN-gamma, IFNg
  • Entrez Gene ID: 15978
  • Molecular mass of antigen [kDa]: 16
  • Distribution of antigen: T cells, B cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE
  • Selected references

    1. Vila-del Sol, V. et al. (2008) IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages. J. Immunol. 181(7): 4461-4470
    2. Gray, P. W. et al. (1983) Cloning and expression of murine immune interferon cDNA. Proc. Natl. Acad. Sci. U.S.A. 80(19): 5842-5846
    3. Chan, E. D. et al. (2001) IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am. J. Physiol., Cell Physiol. 280(3): 441-450
Product options: 4
130-117-780

Anti-IFN-γ-FITC, mouse

30 µg in 200 µL (1)
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130-117-668

Anti-IFN-γ-FITC, mouse

150 µg in 1 mL (1)
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130-117-502

Anti-IFN-γ-PE, mouse

30 µg in 200 µL (1)
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130-117-352

Anti-IFN-γ-PE, mouse

150 µg in 1 mL (1)
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