Anti-Hsp70 antibodies, human and mouse

Clone: REA349 | Dilution: 1:50
Clone REA349 recognizes the human and mouse heat shock 70 kDa protein (Hsp70) antigen, a member of the heat shock protein family that serve critical roles in protein homeostasis. The Hsp70 family is the most conserved in evolution, and all eukaryotes contain multiple members. Their synthesis is increased upon environmental stress. Hsp70 assists a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. It has thus housekeeping functions in the cell in which it is built-in components of folding and signal transduction pathways, and quality control functions in which it proofreads the structure of proteins and repairs misfolded conformers. All of these activities appear to be based on the property of Hsp70 to interact with hydrophobic peptide segments of proteins in an ATP-controlled fashion.
Additional information: Clone REA349 displays negligible binding to Fc receptors.

Alternative Names

HSPA1B, HSPA1A, HSP70-1, HSP70-2, HSP70.1, HSP70.2

Technical specifications

  • Antigen: Hsp70
  • Clone: REA349
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: HSPA1B, HSPA1A, HSP70-1, HSP70-2, HSP70.1, HSP70.2
  • Entrez Gene ID: 3303, 3304
  • Molecular mass of antigen [kDa]: 70
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE

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