Anti-HLA-E antibodies, human

Anti-HLA-E antibodies, human

Clone: 3D12 | Dilution: 1:11
The 3D12 monoclonal antibody recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on NK cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity.

Alternative Names

QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Technical specifications

  • Antigen: HLA-E
  • Clone: 3D12
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E
  • Entrez Gene ID: 3133
  • Molecular mass of antigen [kDa]: 38
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
Product options: 2

Product information

Size
Order no.
Price

Anti-HLA-E-APC, human

  • 3D12
  • 1:11
  • For research use only
for 100
tests
(1)
130-096-846
-

Anti-HLA-E-Biotin, human

  • 3D12
  • 1:11
  • For research use only
for 100
tests
(1)
130-096-890
-

Related products

2 products available