Anti-HLA-DR, DP, DQ antibodies, human

Anti-HLA-DR, DP, DQ antibodies, human

Clone: REA332 | Dilution: 1:50
Clone REA332 recognizes all major histocompatibility class (MHC) class II HLA-DR, DP, and most DQ antigens. Expressed on the surface of most nucleated cells, MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4
+
T cells, MHC class II molecules also mediate the thymic selection of T helper cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases.
Additional information: Clone REA332 displays negligible binding to Fc receptors.

Alternative Names

HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DQB3, HLA-DRA, HLA-DRB1

Technical specifications

  • Antigen: HLA-DR, DP, DQ
  • Clone: REA332
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DQB3, HLA-DRA, HLA-DRB1
  • Entrez Gene ID: 3123, 3122, 3127, 3126, 3125, 16149, 3115, 3113, 3117, 3118, 3119, 3120, 3121
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    common marmoset (
    Callithrix jacchus
    )
  • Distribution of antigen: nucleated cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected References

    1. Denzin, L. et al. (2017) Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity 47(2)
    2. van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285(52): 40800-40808
    3. Jones, E. Y. et al. (2006) MHC class II proteins and disease: a structural perspective. Nat. Rev. Immunol. 6(4): 271-282
    4. Nishimura, Y. et al. (1998) Peptide-based molecular analyses of HLA class II-associated susceptibility to autoimmune diseases. Int. Rev. Immunol. 17(5–6): 229-262
    5. Hoppstädter, J. et al. (2015) M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6
Product options: 2

Product information

Size
Order no.
Price

Anti-HLA-DR, DP, DQ-PE, human

  • REA332
  • 1:50
  • For research use only
for 30
tests
(1)
130-120-784
-

Anti-HLA-DR, DP, DQ-PE, human

  • REA332
  • 1:50
  • For research use only
for 100
tests
(1)
130-120-715
-