Anti-HLA-DR antibodies, human

Anti-HLA-DR antibodies, human

Clone: REA805 | Dilution: 1:50
Clone REA805 recognizes the human major histocompatibility (MHC) class II antigen HLA-DR, a heterodimeric cell surface glycoprotein belonging to the Ig superfamiliy. HLA-DR is constitutively expressed on professional antigen-presenting cells like dendritic cells, B cells, and monocytes/macrophages. Its expression is further up-regulated upon activation. On T cells, NK cells, hematopoietic precursor cells, and some epithelial cells the expression of HLA-DR is induced by cell activation.
Additional information: Clone REA805 displays negligible binding to Fc receptors.

Alternative Names

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the different hybridoma clones. 
Other clonesOverlap in epitope recognition with REA805

Technical specifications

  • Antigen: HLA-DR
  • Clone: REA805
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
  • Entrez Gene ID: 3123, 3122, 3127, 3126, 3125
  • Molecular mass of antigen [kDa]: 27-33
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    african green monkey (
    Chlorocebus aethiops
    , baboon,
    chimpanzee (
    Pan troglodytes
    common marmoset (
    Callithrix jacchus
    cotton-top tamarin (
    Saguinus oedipus
    pigtail monkey (
    Macaca nemestrina
  • Distribution of antigen: dendritic cells, B cells, monocytes, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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