Anti-HLA Class I Bw6 antibodies, human

Anti-HLA Class I Bw6 antibodies, human

Clone: REA143 | Dilution: 1:11
Clone REA143 recognizes HLA Bw6, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Downregulation of HLA class I Bw6 allele has been reported in leukemic patients where it is suggested that via this downregulation, leukemic cells may circumvent attack by CTLs.
Additional information: Clone REA143 displays negligible binding to Fc receptors.

Alternative Names

HLA-B, AS, SPDA1

Technical specifications

  • Antigen: HLA Class I Bw6
  • Clone: REA143
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-B, AS, SPDA1
  • Entrez Gene ID: 3106
  • Molecular mass of antigen [kDa]: 32
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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