Anti-GARP (LRRC32) antibodies, mouse

Anti-GARP (LRRC32) antibodies, mouse

Clone: REA139 | Dilution: 1:10
Clone REA139 recognizes murine GARP, a 80 KDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets and activated GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to nonactive TGFβ. Thus, GARP as a latent TGFβ binding protein (LTBP) regulates the surface expression of TGFβ and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGFβ is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells.
Additional Information: Clone REA139 displays negligible binding to Fc receptors.

Alternative Names

LRRC32, Garpin, Glycoprotein A Repetitions Predominant

Technical specifications

  • Antigen: GARP (LRRC32)
  • Clone: REA139
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: LRRC32, Garpin, Glycoprotein A Repetitions Predominant
  • Entrez Gene ID: 434215
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: T cells, megakaryocytes, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
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