Anti-GARP (LRRC32) antibodies, human

Anti-GARP (LRRC32) antibodies, human

Clone: REA166 | Dilution: 1:11
Clone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β–binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells.
Additional information: Clone REA166 displays negligible binding to Fc receptors.

Alternative Names

LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP)

Technical specifications

  • Antigen: GARP (LRRC32)
  • Clone: REA166
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP)
  • Entrez Gene ID: 2615
  • Molecular mass of antigen [kDa]: 70
  • Distribution of antigen: platelets, other, T cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
Product options: -

Product information

Order no.

Related products

3 products available