Anti-FoxP3 antibodies, human and mouse

Anti-FoxP3 antibodies, human and mouse

Clone: 3G3 | Dilution: 1:50
The Anti-FoxP3 antibody specifically recognizes the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box protein P3, SCURFIN, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression.

Alternative Names

AIID, DIETER, IPEX, JM2, PIDX, XPID, Forkhead box protein P1, SCURFIN

Technical specifications

  • Antigen: FoxP3
  • Clone: 3G3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: AIID, DIETER, IPEX, JM2, PIDX, XPID, Forkhead box protein P1, SCURFIN
  • Entrez Gene ID: 50943
  • Molecular mass of antigen [kDa]: 47
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected References

    1. Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164
    2. Walker, M. R. et al. (2003)
      Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4
      +
      CD25
      -
      T cells.
      J. Clin. Invest. 112: 1437-1443
    3. Lamprecht, B. et al. (2008) Aberrant expression of the Tʜ2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood 112(8): 3339-3347
    4. Hori, S. et al. (2003) Control of regulatory T cell development by the transcription factor FoxP3. Science 299: 1057-1061
    5. Gavin, M. A. et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. U.S.A. 103: 6659-6664
    6. Ziegler, S. F. (2006) FoxP3: of mice and men. Annu. Rev. Immunol. 24: 209-226
    7. Jaeckel, E. et al. (2005) Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54: 306-310

Related products

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Product options: 2

Product information

Size
Order no.
Price

Anti-FoxP3-APC, human and mouse

  • 3G3
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-996
-

Anti-FoxP3-APC, human and mouse

  • 3G3
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-470
-