Anti-FoxP3 antibodies, human and mouse

Anti-FoxP3 antibodies, human and mouse

Clone: 3G3 | Dilution: 1:11
The Anti-FoxP3 antibody specifically recognizes the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box protein P3, SCURFIN, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression.

Alternative Names

AIID, DIETER, IPEX, JM2, PIDX, XPID

Technical specifications

  • Antigen: FoxP3
  • Clone: 3G3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: AIID, DIETER, IPEX, JM2, PIDX, XPID
  • Entrez Gene ID: 50943
  • Molecular mass of antigen [kDa]: 47
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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