Anti-FcεRIα antibodies – functional grade, mouse

Anti-FcεRIα antibodies – functional grade, mouse

Clone: MAR-1
Clone MAR-1 detects the alpha subunit of the murine high-affinity Fc receptor for IgE. The receptor is composed of one alpha-, one beta-, and two disulfid-linked gamma subunits, of which the alpha subunit binds IgE. FcεRIα is expressed on mast and basophilic cells and is up-regulated in the presence of IgE. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.

Applications

The Anti-FcεRIα pure – functional grade antibody is suited for functional assays, for example, blocking of receptor-ligand binding.

Alternative names

FCER1A, FcERI, Fce1a, Fcr-5

Technical specifications

  • Antigen: FcεRIα
  • Clone: MAR-1
  • Isotype: hamster IgG
  • Alternative names of antigen: FCER1A, FcERI, Fce1a, Fcr-5
  • Entrez Gene ID: 14125
  • Molecular mass of antigen [kDa]: 26
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
  • Selected references

    1. Metzger, H. et al. (1989) The receptor with high affinity for IgE. Ciba Found. Symp. 147: 93-113
    2. Yamaguchi, M. et al. (2001) Regulation of mouse mast cell surface Fc epsilon RI expression by dexamethasone. Int. Immunol. 13: 843-851
    3. Kojima, T. et al. (2007)
      Mast cells and basophils are selectively activated
      in vitro
      and
      in vivo
      through CD200R3 in an IgE-independent manner.
      J. Immunol. 179: 7093-7100
Product options: 1
130-096-083

Anti-FcεRIα pure - functional grade, mouse

100 µg in 1 mL
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