Anti-EZH2 antibodies, human and mouse

Anti-EZH2 antibodies, human and mouse

Clone: REA907 | Dilution: 1:50
Clone REA907 recognizes the human and mouse EZH2 protein, a methyltransferase which plays an essential role in the regulation of homeobox gene expression. EZH2, also known as enhancer of zeste homolog 2, belongs to the polycomp group (PcG). Members of this family play an essential role in stem-cell identity as well as cellular differentiation during development via transcriptional repression and disease. EZH2, first described in drosophila, is found in higher levels in different kind of tumor cells, and it is also expressed in thymocytes, and, depending on their stage, subsets of T cells and B cells.
Additional information: Clone REA907 displays negligible binding to Fc receptors.

Alternative names

Enhancer of zeste homolog 2, KMT6

Technical specifications

  • Antigen: EZH2
  • Clone: REA907
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: Enhancer of zeste homolog 2, KMT6
  • Entrez Gene ID: 14056, 2146
  • Molecular mass of antigen [kDa]: 85
  • Cross-reactivity: rat, dog, chicken
  • Distribution of antigen: T cells, B cells, tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515
  • Selected references

    1. Chen, H. et al. (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38(1): 30-37
    2. Sauvageau, M. and Sauvageau, G. (2008) Polycomb group genes: keeping stem cell activity in balance. PLoS Biol. 6(4): e113
    3. Di Croce, L. et al. (2013) Transcriptional regulation by Polycomb group proteins. Nat. Struct. Mol. Biol. 20(10): 1147-1155
Product options: 8
130-115-317

Anti-EZH2-FITC, human and mouse

for 30
tests
(1)
-
130-115-218

Anti-EZH2-FITC, human and mouse

for 100
tests
(1)
-
130-115-318

Anti-EZH2-PE, human and mouse

for 30
tests
(1)
-
130-115-219

Anti-EZH2-PE, human and mouse

for 100
tests
(1)
-
130-115-319

Anti-EZH2-APC, human and mouse

for 30
tests
(1)
-
130-115-220

Anti-EZH2-APC, human and mouse

for 100
tests
(1)
-
130-115-320

Anti-EZH2-Vio515, human and mouse

for 30
tests
(1)
-
130-115-221

Anti-EZH2-Vio515, human and mouse

for 100
tests
(1)
-