Anti-DO11.10 TCR antibodies – functional grade, mouse

Anti-DO11.10 TCR antibodies – functional grade, mouse

Clone: KJ1-26
The DO11.10 mouse model is a valuable tool for studies of T cell immigration, immunoregulation, development, activation, and function. The KJ1-26 monoclonal antibody reacts with the T cell receptor (TCR) expressed on lymphocytes of the DO11.10 transgenic mouse and the TCR of the BALB/c-derived DO11.10 and DO11.10.24 T cell hybridoma. The DO11.10 TCR is specific for the chicken ovalbumin (OVA) peptide (323-339) in the context of I-A[d] major histocompatibility (MHC) molecules. Transgenic DO11.10 T cells also recognize OVA peptide from jungle fowl and turkey in the presence of A20-1.11, the H-2
d
-bearing, antigen-presenting B cell lymphoma.

Applications

The Anti-DO11.10 TCR pure – functional grade antibody is suited for functional assays, for example, blocking of antigen response of DO11.10 T cell hybridoma.

Alternative Names

TCRA, Tcralpha

Technical specifications

  • Antigen: DO11.10 TCR
  • Clone: KJ1-26
  • Isotype: mouse IgG2a
  • Alternative names of antigen: TCRA, Tcralpha
  • Entrez Gene ID: 21473
  • Distribution of antigen: T cells
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected References

    1. Haskins, K. et al. (1983) The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157(4): 1149-1169
    2. Marrack, P. et al. (1983) The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. J. Exp. Med. 158(5): 1635-1646
    3. Murphy, K. M. et al. (1990)
      Induction by antigen of intrathymic apoptosis of CD4
      +
      CD8
      +
      TCR
      lo
      thymocytes
      in vivo
      .
      Science 250(4988): 1720-1723
Product options: 1

Product information

Size
Order no.
Price

Anti-DO11.10 TCR pure - functional grade, mouse

  • KJ1-26
  • For research use only
500 µg in 0.5 mL
130-095-379
-