Anti-DLL4 antibodies, human

Anti-DLL4 antibodies, human

Clone: REA1065 | Dilution: 1:50
Clone REA1065 recognizes the human delta-like4 (DLL4) antigen, which is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation.
Additional information: Clone REA1065 displays negligible binding to Fc receptors.

Alternative names

hdelta2, Delta-like4, Delta-like protein 4

Technical specifications

  • Antigen: DLL4
  • Clone: REA1065
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: hdelta2, Delta-like4, Delta-like protein 4
  • Entrez Gene ID: 54567
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: dendritic cells, endothelial cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037
    2. Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122): 1083-1087
    3. Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205(11): 2515-2523
    4. Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205(11): 2507-2513
    5. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32: 14-27
Product options: 22
130-118-378

Anti-DLL4-FITC, human

for 30
tests
(1)
-
130-118-224

Anti-DLL4-FITC, human

for 100
tests
(1)
-
130-118-379

Anti-DLL4-PE, human

for 30
tests
(1)
-
130-118-225

Anti-DLL4-PE, human

for 100
tests
(1)
-
130-118-380

Anti-DLL4-APC, human

for 30
tests
(1)
-
130-118-226

Anti-DLL4-APC, human

for 100
tests
(1)
-
130-118-381

Anti-DLL4-VioBlue, human

for 30
tests
(1)
-
130-118-227

Anti-DLL4-VioBlue, human

for 100
tests
(1)
-
130-118-382

Anti-DLL4-VioGreen, human

for 30
tests
(1)
-
130-118-228

Anti-DLL4-VioGreen, human

for 100
tests
(1)
-
130-118-383

Anti-DLL4-PE-Vio615, human

for 30
tests
(1)
-
130-118-229

Anti-DLL4-PE-Vio615, human

for 100
tests
(1)
-
130-118-384

Anti-DLL4-PE-Vio770, human

for 30
tests
(1)
-
130-118-230

Anti-DLL4-PE-Vio770, human

for 100
tests
(1)
-
130-118-385

Anti-DLL4-APC-Vio770, human

for 30
tests
(1)
-
130-118-231

Anti-DLL4-APC-Vio770, human

for 100
tests
(1)
-
130-118-386

Anti-DLL4-PerCP-Vio700, human

for 30
tests
(1)
-
130-118-232

Anti-DLL4-PerCP-Vio700, human

for 100
tests
(1)
-
130-118-387

Anti-DLL4-VioBright 515, human

for 30
tests
(1)
-
130-118-233

Anti-DLL4-VioBright 515, human

for 100
tests
(1)
-
130-118-388

Anti-DLL4-Biotin, human

for 30
tests
(1)
-
130-118-234

Anti-DLL4-Biotin, human

for 100
tests
(1)
-