Anti-Dectin-2 antibodies, mouse

Anti-Dectin-2 antibodies, mouse

Clone: KVa7-6E7 | Dilution: 1:10
Clone KVa7-6E7 specifically recognizes mouse dendritic cell–associated C-type lectin 2 (Dectin-2). Dectin-2 is a type II membrane protein and contains a single carbohydrate recognition domain. Like other C-type lectins, mouse Dectin-2 has conserved motifs for the Ca
2+
-dependent recognition of mannose. Dectin-2 is located in the natural killer gene complex of chromosome 6. Genomic analyses show that beside a full length Dectin-2 transcript two truncated isoforms are produced by alternative splicing, encoding transmembrane proteins of 168–209 amino acids.¹
,
² The expression of Dectin-2 on mouse monocytes and macrophages can be induced by zymosan and thioglycollate.
3
Dectin-2 plays a physiological role in antigen presentation and antigen targeting via Dectin-2 can induce a CD8
+
T cell response.
4

Alternative Names

CLEC4N, Clec6a, Clecsf10, Nkcl

Technical specifications

  • Antigen: Dectin-2
  • Clone: KVa7-6E7
  • Isotype: rat IgG2a
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: CLEC4N, Clec6a, Clecsf10, Nkcl
  • Entrez Gene ID: 56620
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, pure
  • Selected References

    1. Fernandes, M. J. et al. (1999) Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 59: 2709-2717
    2. Ariizumi, K. et al. (2000) Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275: 11957-11963
    3. Taylor, P. R. et al. (2005)
      Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited
      in vivo
      .
      Eur. J. Immunol. 35: 2163-2174
    4. Carter, R. W. et al. (2006)
      Induction of CD8
      +
      T cell responses through targeting of antigen to Dectin-2.
      Cell. Immunol. 239: 87-91
Product options: 3

Product information

Size
Order no.
Price

Anti-Dectin-2-FITC, mouse

  • KVa7-6E7
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-103-011
-

Anti-Dectin-2-FITC, mouse

  • KVa7-6E7
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-102-212
-

Anti-Dectin-2 pure, mouse

  • KVa7-6E7
  • For research use only
100 µg in 1 mL
130-094-481
-