Anti-Dectin-1 antibodies, mouse

Anti-Dectin-1 antibodies, mouse

Clone: REA154 | Dilution: 1:10
Clone REA154 recognizes murine dectin-1, which is approximately 40 kDa type II transmembrane protein, also known as mouse beta-glucan receptor or CLEC7A. It promotes the phagocytosis of intact yeasts and glucan particles such as β-1,3-linked and β-1,6-glucans, thus playing an important role in anti-fungal immunity. Neutrophils and macrophages express relatively higher levels of dectin-1 as compared to dendritic cells and subpopulation of T cells. In cooperation with TLR2 and TLR4, dectin-1 leads to cytokine production in human macrophages and monocytes.
Additional information: Clone REA154 displays negligible binding to Fc receptors.

Alternative Names

CLEC7A, BGR, CLECSF12, beta-GR, βGR

Technical specifications

  • Antigen: Dectin-1
  • Clone: REA154
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CLEC7A, BGR, CLECSF12, beta-GR, βGR
  • Entrez Gene ID: 56644
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: T cells, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
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