Anti-DCAR1 antibodies, mouse

Anti-DCAR1 antibodies, mouse

Clone: SKa5-3D5 | Dilution: 1:10
Dendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a
+
DC subsets in spleen and thymus and on subsets of CD11b
+
myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses
in vivo
. Triggering DCAR1 via monoclonal antibody ligation on CD8
+
DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice.

Alternative Names

CLEC4B1, Aplra2, Clec4b, DCAR, DCARbeta, Dcar2

Technical specifications

  • Antigen: DCAR1
  • Clone: SKa5-3D5
  • Isotype: rat IgG2b
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: CLEC4B1, Aplra2, Clec4b, DCAR, DCARbeta, Dcar2
  • Entrez Gene ID: 69810
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
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