Anti-CXCL9 (MIG) antibodies, mouse

Anti-CXCL9 (MIG) antibodies, mouse

Clone: REA365 | Dilution: 1:10
Clone REA365 recognizes the mouse C-X-C motif chemokine ligand 9 (CXCL9) antigen, a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by interferon γ (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ during infection, injury or immunoinflammatory responses in macrophages, hepatocytes, and endothelial cells. It is best known for its role in leucocyte trafficking, principally acting on activated CD4
+
Th1 cells, CD8
+
T cells and NK cells. CXCL9 also has angiostatic properties. Overexpression of CXCL9 in tumors can lead to T-cell accumulation, vascular damage, and tumor regression. It elicits its chemotactic functions by interacting with the chemokine receptor CXCR3.
Additional information: Clone REA365 displays negligible binding to Fc receptors.

Alternative Names

CMK, γ-interferon-induced monokine, MuMIG, Scyb9, crg-10, MIG

Technical specifications

  • Antigen: CXCL9 (MIG)
  • Clone: REA365
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CMK, γ-interferon-induced monokine, MuMIG, Scyb9, crg-10, MIG
  • Entrez Gene ID: 17329
  • Molecular mass of antigen [kDa]: 12
  • Distribution of antigen: T cells, macrophages, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected References

    1. Giegold, O. et al. (2013) CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J. Immunol. 190(7): 3696-3705
    2. Kastenmüller, W. et al. (2013)
      Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8
      +
      T cell responses in the lymph node.
      Immunity 38(3): 502-513
    3. Farber, J. M. et al. (1990) A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. U.S.A. 87(14): 5238-5242
Product options: 4

Product information

Size
Order no.
Price

Anti-CXCL9 (MIG)-PE, mouse

  • REA365
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-207
-

Anti-CXCL9 (MIG)-PE, mouse

  • REA365
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-148
-

Anti-CXCL9 (MIG)-APC, mouse

  • REA365
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-208
-

Anti-CXCL9 (MIG)-APC, mouse

  • REA365
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-149
-