Anti-CXCL16 antibodies, human

Anti-CXCL16 antibodies, human

Clone: REA873 | Dilution: 1:50
Clone REA873 recognizes the human CXCL16 cytokine belonging to the CXC chemokine family. It consists of a transmembrane region and a chemokine domain suspended by a mucin-like stalk. CXCL16 is secreted by dendritc cells localized in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. The expression of CXCL16 is induced by the inflammatory cytokines IFN-γ and TNF-α. The receptor of CXCL16 is CD186, also known as CXCR6, Bonzo, or STRL33, which is activated by CXCL16, which leads to chemotaxis of T cells.
Additional information: Clone REA873 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: CXCL16
  • Clone: REA873
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 58191
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: T cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected References

    1. Matloubian, M. et al. (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat. Immunol. 1(4): 298-304
    2. Wilbanks, A. et al. (2001) Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines. J. Immunol. 166(8): 5145-5154
    3. Abel, S. et al. (2004) The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J. Immunol. 172(10): 6362-6372

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