Anti-CLEC2A antibodies, human

Anti-CLEC2A antibodies, human

Clone: REA544 | Dilution: 1:11
Clone REA544 recognizes the human CLEC2A antigen, which is a member of the C-type lectin-like domain–containing family. It enhances TCR-stimulated T cell expansion by upregulating anti-apoptotic proteins and may modulate the capacity of T cells to home to lymph nodes through SELL. It facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. In contrast to the other CLEC2 family members AICL, CD69, and LLT1, CLEC2A is predominantly expressed in skin.
Additional information: Clone REA544 displays negligible binding to Fc receptors.

Alternative names

INPE5792, KACL, PILAR, UNQ5792, CLEC-2A

Technical specifications

  • Antigen: CLEC2A
  • Clone: REA544
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: INPE5792, KACL, PILAR, UNQ5792, CLEC-2A
  • Entrez Gene ID: 387836
  • Molecular mass of antigen [kDa]: 20
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Huarte, E. et al. (2008) PILAR is a novel modulator of human T-cell expansion. Blood 112(4): 1259-1268
    2. Spreu, J. et al. (2010) Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 107(11): 5100-5105
Product options: 6
130-108-747

Anti-CLEC2A-PE, human

for 30
tests
(1)
-
130-108-679

Anti-CLEC2A-PE, human

for 100
tests
(1)
-
130-108-748

Anti-CLEC2A-APC, human

for 30
tests
(1)
-
130-108-680

Anti-CLEC2A-APC, human

for 100
tests
(1)
-
130-108-273

Anti-CLEC2A-Biotin, human

for 30
tests
(1)
-
130-108-246

Anti-CLEC2A-Biotin, human

for 100
tests
(1)
-