Anti-Claudin-4 antibodies, human

Anti-Claudin-4 antibodies, human

Clone: REA898 | Dilution: 1:50
Clone REA898 recognizes the human claudin-4 antigen, an integral membrane protein with four transmembrane segments, which is a component of the claudin family of epithelial tight junction proteins. Claudin is found in the intestinal mucosa epithelium and is highly expressed in pancreatic cancer. In association with EphA2 Claudin-4 is inveolved in the regulation of tight juctions and it plays a role in epithelial tissue development.
Additional information: Clone REA898 displays negligible binding to Fc receptors.

Alternative names

CLDN4, CPER, CPE-R, CPETR1, WBSCR8

Technical specifications

  • Antigen: Claudin-4
  • Clone: REA898
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CLDN4, CPER, CPE-R, CPETR1, WBSCR8
  • Entrez Gene ID: 1364
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: pancreatic carcinoma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Michl, P. et al. (2003) Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res. 63(19): 6265-6271
    2. Tanaka, M. et al. (2005) EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. J. Biol. Chem. 280(51): 42375-42382
Product options: 8
130-114-911

Anti-Claudin-4-FITC, human

for 30
tests
(1)
-
130-114-869

Anti-Claudin-4-FITC, human

for 100
tests
(1)
-
130-114-912

Anti-Claudin-4-PE, human

for 30
tests
(1)
-
130-114-870

Anti-Claudin-4-PE, human

for 100
tests
(1)
-
130-114-913

Anti-Claudin-4-APC, human

for 30
tests
(1)
-
130-114-871

Anti-Claudin-4-APC, human

for 100
tests
(1)
-
130-114-910

Anti-Claudin-4-Biotin, human

for 30
tests
(1)
-
130-114-868

Anti-Claudin-4-Biotin, human

for 100
tests
(1)
-