Anti-CLA antibodies, human

Anti-CLA antibodies, human

Clone: REA1101 | Dilution: 1:50
Clone REA1101 recognizes the cutaneous lymphocyte-associated antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1). It serves as a ligand for selectins, including CD62E (ELAM-1) and CD62L (LECAM-1). CLA is a unique skin-homing receptor and is predominantly found on a minor subset of human T cells that infiltrate the skin. This post-translational modification of PSGL-1 is thought to serve as a mechanism to regulate tissue-specific homing of CD4
+
and CD8
+
memory/effector T cells from peripheral blood to the skin, which plays an essential role during many inflammatory and certain malignant skin diseases. In peripheral blood, CLA is not only found on skin-homing memory/effector T cells, but is also found to be expressed on memory/effector B cells, NK cells, blood dendritic cells, and on monocytes. CLA is furthermore found on Langerhans cells in the skin.
Additional information: Clone REA1101 displays negligible binding to Fc receptors.

Alternative Names

SELPLG, CD162, PSGL-1, PSGL1

Technical specifications

  • Antigen: CLA
  • Clone: REA1101
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SELPLG, CD162, PSGL-1, PSGL1
  • Entrez Gene ID: 6404
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: dendritic cells, Langerhans cells, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PerCP-Vio700
Product options: 6

Product information

Size
Order no.
Price

Anti-CLA-PE, human

  • REA1101
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-220
-

Anti-CLA-PE, human

  • REA1101
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-043
-

Anti-CLA-APC, human

  • REA1101
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-221
-

Anti-CLA-APC, human

  • REA1101
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-044
-

Anti-CLA-PerCP-Vio700, human

  • REA1101
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-226
-

Anti-CLA-PerCP-Vio700, human

  • REA1101
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-049
-

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