Anti-CLA antibodies, human

Anti-CLA antibodies, human

Clone: HECA-452 | Dilution: 1:11
The Anti-CLA antibody recognizes the cutaneous lymphocyte-associated antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1). It serves as a ligand for selectins, including CD62E (ELAM-1) and CD62L (LECAM-1). CLA is a unique skin-homing receptor and is predominantly found on a minor subset of human T cells that infiltrate the skin. This post-translational modification of PSGL-1 is thought to serve as a mechanism to regulate tissue-specific homing of CD4
+
and CD8
+
memory/effector T cells from peripheral blood to the skin, which plays an essential role during many inflammatory and certain malignant skin diseases.
In peripheral blood, CLA is not only found on skin-homing 
memory/effector T cells, but is also found to be expressed on memory/effector B cells, NK cells, blood dendritic cells, and on monocytes. CLA is furthermore found on Langerhans cells in the skin.

Alternative Names

SELPLG, CD162, PSGL-1, PSGL1

Technical specifications

  • Antigen: CLA
  • Clone: HECA-452
  • Isotype: rat IgMκ
  • Isotype control: Rat IgM – isotype control antibodies
  • Alternative names of antigen: SELPLG, CD162, PSGL-1, PSGL1
  • Entrez Gene ID: 6404
  • Molecular mass of antigen [kDa]: 39
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin, pure
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