Anti-ChemR23 (CMKLR1) antibodies, mouse

Anti-ChemR23 (CMKLR1) antibodies, mouse

Clone: REA461 | Dilution: 1:10
Clone REA461 recognizes the mouse G-protein coupled receptor ChemR23 antigen, a multi-pass membrane protein, which is also known as chemokine-like receptor 1 (CMKLR1). During dendritic cell (DC) differentiation from bone marrow, ChemR23 is upregulated early and then diminishes with time in culture. Most DC
in vivo
do not detectably express the receptor. In contrast, freshly isolated F4/80
+
/CD11b
+
mouse peritoneal macrophages express ChemR23, display calcium signaling and migration to the active ligand. A small population of blood-borne F4/80
+
/CD11b
+
macrophages also expresses ChemR23. Its natural ligand, chemerin, acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation and phosphorylation of ERK-1/ERK-2 MAP kinases. ChemR23 positively regulates adipogenesis and adipocyte metabolism.
Additional information: Clone REA461 displays negligible binding to Fc receptors.

Alternative Names

Cmklr1, Dez, Gpcr27, mcmklr1

Technical specifications

  • Antigen: ChemR23 (CMKLR1)
  • Clone: REA461
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Cmklr1, Dez, Gpcr27, mcmklr1
  • Entrez Gene ID: 14747
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: dendritic cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
Product options: 8

Product information

Size
Order no.
Price

Anti-ChemR23 (CMKLR1)-PE, mouse

  • REA461
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-106-966
-

Anti-ChemR23 (CMKLR1)-PE, mouse

  • REA461
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-106-902
-

Anti-ChemR23 (CMKLR1)-APC, mouse

  • REA461
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-106-967
-

Anti-ChemR23 (CMKLR1)-APC, mouse

  • REA461
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-106-903
-

Anti-ChemR23 (CMKLR1)-PE-Vio770, mouse

  • REA461
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-106-968
-

Anti-ChemR23 (CMKLR1)-PE-Vio770, mouse

  • REA461
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-106-904
-

Anti-ChemR23 (CMKLR1)-Biotin, mouse

  • REA461
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-107-010
-

Anti-ChemR23 (CMKLR1)-Biotin, mouse

  • REA461
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-106-949
-

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